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METOLOSE® SM 4 - Excipient - Pelliculage granules - masquage de gout

METOLOSE® SM 4

Low-viscosity methylcellulose for film-coating of granules

METOLOSE® SM-4 is a low-viscosity methylcellulose specially designed for film-coating of granules and pellets in fluidised bed.

The METOLOSE® range from SHIN ETSU is compliant with Ph.Eur, JP and USP.

Film-coating of granules and taste masking

In fluidised bed systems, the film-coating of granules and pellets in aqueous medium can be complicated by adhesion phenomena.

METOLOSE® SM-4 is only slightly adhesive and can be used to obtain a fine, consistent film-coating of granules and pellets using fluidised air bed systems without agglomeration due a reduced adhesiveness.

At a spray rate of 80 g/min, fewer than 5% of 1 mm granules are agglomerated while with hypromellose, this rate is almost 50% for the same spraying speed.

  • The granules film-coated with METOLOSE® SM-4 do not show any dispersion delay.
  • The product is used at a concentration of 7% in aqueous medium.
  • METOLOSE® SM-4 also has taste masking properties.
  • METOLOSE® SM-4 is manufactured in accordance with the Good Manufacturing Practices applicable to excipients.

All the regulatory and quality documents needed for registration are available on request.

Supplier

The Japanese company SHIN ETSU is a leader in cellulose chemistry.
SHIN ETSU develops pharmaceutical excipients and particularly cellulosic polymers for a range of applications such as film-coating, compression and matrices.

SEPPIC™ distributes SHIN ETSU products in Western and Southern Europe and several other countries.

SHIN ETSU

Resources

Safety Data Sheet

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