Ingredients for the parenteral routeExcipients for a rapid administration
The parenteral - or injectable - route controls dosage, avoids side effects associated with the first intestinal and hepatic passage, and delivers medication continuously by infusion.
Regardless of the injectable drugs developed or the type of administration (intravenous, subcutaneous, intramuscular, or ocular), drugs can be designed with one or more of our excipients to improve the solubility, stability, safety, and efficacy of the active ingredient.
Our injectable excipients are manufactured with the same quality standards as active pharmaceutical ingredients. They comply with Good Manufacturing Practice (GMP) Part II guidelines and current pharmacopeias.
Solubilisers and Emulsifiers to solve Bioavailability issues
Formulators often face challenges with bioavailability concerning active ingredients, mainly related to their solubility. An increasing amount of therapeutic molecules currently under development are poorly water-soluble. It is estimated that up to 70% of new chemical entities (NCEs) present a bioavailability issue. Our solubilisers and emulsifiers meet the solubility challenges presented by active ingredients.
Drugs can be formulated with an emulsion as a carrier. Depending on the type of emulsion — water-in-oil or oil-in-water — emulsifiers are selected according to their lipophilic/hydrophilic nature. Our emulsifiers have additional functions due to their hydrophilic/lipophilic ratio, such as anti-foaming, wetting, foaming, and solubilization functions.
Formulation of biological drugs
Biological products, such as monoclonal antibodies, are rapidly being developed. The challenges in these formulations are not only in the solubilization of certain proteins but also in their aggregation, a problem specific to biological drugs that can lead to a loss of efficacy and undesired immunogenicity. In response to this issue, Seppic offers surfactants dedicated to parenteral use.