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Acides-Aminés-Acylation-Lipoaminoacides- technologie

Amino Acids Acylation Technology

Creation of fully characterized bio-based ingredients

Combining bio-based ingredients with a clearly defined structure and benefit for the end user is a challenge when creating ingredients.
Amino acids acylation technology provides an ideal solution by producing bio-based (anionic) amphiphilic molecules: LipoAminoAcids (LAA) formed of a polar head group derived from amino acids, (oligo)peptides or protein hydrolysates, and a lipophilic hydrocarbon chain from carboxylic acids from the vegetable oil sector.

Why choose amino acids as a source?

Amino acids are a family of molecules that are omnipresent in nature. They are the essential constituents of the proteins that are found in the body of every living creature. Amino acids therefore play a decisive role in both the structure of living organisms and in biological metabolisms. They are coded by the cellular DNA of all known living organisms.

Amino acids are carboxylic acids with a functional amino group; with the basic structure H₂N–CNR–COOH, they are differentiated by the nature of the side chain R.

Examples of amino acids essential for the protection and vitality of skin and hair

What are the main benefits of acylation technology?

Since amino acids are naturally occurring hydrophilic molecules, potentially anionic or cationic depending on the pH, their solubilization in hydrophobic media is improved by giving them an amphiphilic character by simply grafting one or more hydrocarbon chains (lyophilization). This modification facilitates their vectorization in living environments and increases their bioavailability.

Acylation technology is used to vectorize amino acids and improve their bioavailability.

Lyophilization processes are favourably completed in a single step at ambient temperature without sophisticated catalysts. The lipophilic chains are mainly derived from fatty acids, which themselves come from the oleochemical industry. After this transformation, the lipophilic amino acids, now called LipoAminoAcids (LAA), can be presented in two forms: either as aqueous solutions with an LAA concentration of between 20% and 40%, or in powder form with a high LAA concentration (>90%). In both cases, the compositions, liquid or solid are perfectly defined and each constituent is analytically quantified.

Lipophilization reaction

Multiple options for creating ingredients

Amino acids acylation technology creates multiple opportunities for creating ingredients with different functionalities.

Bio-based surfactants for cleaning skin and hair

For example, amino acids acylation technology has produced two gentle cleansing surfactants in aqueous solution, one based on the reconstituted aminogram of oats (bio-based content=55% of the dry product), the other one a reconstituted aminogram of apple (bio-based content=35% of the dry product). In addition to their safety, these surfactants offer two main benefits for the consumer: 

  • High foaming power with great stability of the foam in the presence of hard water and dirt
  • A tight foam, with a soft and creamy skin feel

Active ingredients for beauty or health

By combining the various amino acids and fatty acids existing in nature, acylation technology is also an inexhaustible source for creating concentrated active ingredients (purity quantified by chromatography>90%) with a great variety of biological targets.

Sustainable performance ingredients

Amino acids acylation technology can be used to create performance ingredients that are innovative due to their sustainable nature: 

  • Foams for tunnel drilling and groundwater operations (lubrication, removal of excavated materials) using biodegradable, non-ecotoxic and non-bioaccumulative products,
  • Ingredients for the cement industry, fire-fighting, the elicitation of plants, etc.
Examples of ingredient creation

Testimonial

“In 10 years, the acylation technology has allowed us to create a bank of more than one hundred molecules which, after analytical characterization and biological screening, gave birth to new efficient actives ingredients for beauty care.”

Jérôme Guilbot , Innovation and Development manager of surfactants and bio-based actives