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METOLOSE® SH/SM - METOLOSE® SR - Hypromellose - Cellulose Ether - thickening - viscosity-enhancing - hydrophilic matrices - extended release - tablets

METOLOSE® SH/SM METOLOSE® SR

Thickening agent
Formation of hydrophilic matrices

METOLOSE® SH and SM are cellulose ethers used for their thickening and viscosity-enhancing properties.

METOLOSE® SR products are high-viscosity hypromelloses that allow the formulation of hydrophilic matrices for the extended release of nutritional active ingredients.

METOLOSE® SH and SM

METOLOSE® SH and SM are hypromelloses and ethyl celluloses. Depending on the degree and nature of the cellulose substitution, METOLOSE® SH and SM have different properties:

  • Taste masking
  • Viscosity-enhancing - Thickening
  • Stabilization of emulsions and suspensions

METOLOSE® SH and SM are stable in the presence of electrolytes and across a wide pH range. They are characterised by their viscosity, at a concentration of 2% in aqueous solution, together with the degree of cellulose substitution.

The table below presents the different available grades along with their principal applications:

Type Viscosity (cP) Methoxy (%) Hydroxypropoxy (%) Main Application
SM
Methylcellulose
15
25
100
400
1500
4000
29 - Binder
Dispersing agent
60SH Hypromellose 2910 50 4000 10000 29 9 Thickener for clear solution
65SH
Hypromellose 2906
50
400
4000
29 7 Dispersing agent
90SH
Hypromellose 2208
4000 23 8 Thickener

 
All the grades presented here are suitable for dietary supplement applications in Europe.
They also comply with Ph.Eur, JP and USP.

METOLOSE® SR

METOLOSE® SR products are high-viscosity hypromelloses used for the formation of hydrophilic matrices that control the release of nutritional active ingredients in the body.

METOLOSE® SR products have many properties:

  • Gradual and controlled release of the nutritional active ingredient
  • Control of the dissolution profile by:
    • The percentage of HPMC in tablets
    • Selection of the viscosity
    • Tablet size
  • Improved bioavailability of nutritional active ingredients
  • Direct compression
  • Rapid hydration


The type of substitution of METOLOSE® SR products impacts the product's hydration and the strength of the gel formed. The greater the viscosity, the stronger the gel and the slower the dissolution.

Products from the METOLOSE® SR range can be used in direct compression or wet granulation.

All the grades presented here are suitable for dietary supplement applications in Europe.
They also comply with Ph.Eur, JP and USP.

SHIN ETSU

Supplier

The Japanese company SHIN ETSU is a leader in cellulose chemistry.
SHIN ETSU develops pharmaceutical excipients and particularly cellulosic polymers for a range of applications such as film-coating, compression and matrices, etc.

SEPPIC distributes SHIN ETSU products in Western Europe, Southern Europe and several other countries. Contact us for more information.

Resources

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