Microcrystalline cellulose (MCC) used as compression excipients
CEOLUS™ is a range of microscrystalline cellulose products used as compression excipients. Ceolus™ products facilitate powder or microgranule compression, even at low concentrations in excipients. They also prevent capping during the compression phase. CEOLUS™ has three types of powder grades : UF, KG and PH which comply with USP/NF, Ph.Eur and JP pharmacopeia. It also has a colloidal grade known as RC which complies with USP/NF and JPE pharmacopeia.
Features and functions
Various CEOLUS™ grades have the following characteristics in pharmaceutical formulations:
- Excellent compactibility due to high plastic deformation
- Favorable disintegration while keeping high compactibility
- Improvement in flow due to density and/or morphology
- Good mixing properties helping to prevent particle segregation
- Wide granulation range due to optimal water holding capacity
With their good compactibility, CEOLUS™ UF and KG facilitate formulation design and tabletting efficiency, particularly for high dose, small tablet, and low-compactibility drug formulations.
CEOLUS™ PH grades are the most commonly used grades for oral solid dosage forms. They show excellent performance when used in granulation and direct compression of tablets.
CEOLUS™ RC, the colloidal grade composed of MCC.
They are various CEOLUS grades that have the following CEOLUS™ products that differ in density or angle of repose, characterizing compactibility and flowability properties formulation :
|Grade||Particle size (µm)||Density (g/cm3)||Angle of repose (°)||Main features|
UF, KG and PH grades conform to the current USP/NF, Ph.Eur et JP. RC grade conforms to the current USP/NF and JPE.
CEOLUS™ is manufactured following the current excipient Good Manufacturing Practices (GMPs).
The regulatory and quality package is available on request.
CEOLUS™ is manufactured by Asahi Kasei Corporation.
Asahi Kasei Corporation is a Japanese company who is manufacturing mineral products and cellulose derivatives for a multitude of pharmaceutical applications.
SEPPIC distributes these products in Europe for Spain, France, Italy and Portugal.