SEPITRAP™

Powder solubilizing agent for solid oral forms
Innovative dry powdered surfactant to improve the solubility and bioavailability of your active ingredients by dry process

SEPITRAP™ offers new prospects for formulation and improving the bioavailability of active ingredients with low solubility.

Description

SEPITRAP™ is a micro-encapsulated solubilizer in powder form designed to simplify the manufacturing of solid oral form drugs. It is manufactured by adsorption of the solubilizer in liquid form on a porous support.

SEPITRAP™ is both a solid solubilizer and a compression agent. It is a functional excipient designed specifically to simplify manufacturing of dry-form drugs while improving bioavailability of the active ingredient.

There are two solubilizers in the SEPITRAP™ range:

Grade	Surfactant	Porous Mineral Carrier
SEPITRAP™ 80	Polysorbate 80 (45-65%)	Magnesium Aluminometasilicate (35-55%)
SEPITRAP™ 4000	Polyoxyl 40 hydrogenated castor oil (55-75%)	Magnesium Aluminometasilicate (25-45%)

All the components of SEPITRAP™ comply with USP-NF. SEPITRAP™ is manufactured in accordance with IPEC GMP standards and is certified EXCiPACT.

The regulatory and quality package is available on request.

Process and bioavailability benefits

Designed for solid forms such as tablets and capsules, SEPITRAP™ can be used in direct compression procedures without impacting the hardness and disintegration of the formed tablets.

There are two kinds of benefits: bioavailability enhancement and manufacturing process optimization:

SEPITRAP™ is designed using a patented technology
It is a free-flowing powder
It is suited to direct compression processes, there is no intermediary wet granulation required
It can be used to improve the solubility of active ingredients with low water solubility