EU07475P Quasi-Anhydrous PEG 400-Rich Cream-Gel
Less than 1% water and high amount of PEG 400 for API stabilization & solubilization
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PEG 400 is an essential solvent in topical formulation, though notoriously difficult to thicken and stabilize as well as having a negative texture impact when used at high concentration.
This formula achieves both a high level of PEG 400 for API solubilization and in a quasi-anhydrous dosage form for stabilization of water-sensitive APIs.
With SEPINEO™ P 600
Stabilization of more than 50% of PEG 400
As an inverse latex polymer SEPINEO™ P 600 has strong thickening capacities of polar solvents, including PEG 400, diethylene glycol monoethyl ether, propylene glycol, ethanol, …
Oil-stabilization, unique amongst pharmaceutical polymers
Through its elastic polymer network SEPINEO™ P 600 can stabilize up to 40% of any kind of oil phase without additional surfactant addition, in a simple and flexible process.
Texture improvement
Starting from 0.5% addition, SEPINEO™ P 600 drives the texture of the final dosage form.
- Good skin adhesion
- Easy skin spreading
- Improved sensorial profile
