The main challenge that formulation scientists are facing in topical drug development is to build a dosage form that can stabilize and deliver APIs without compromising on patient compliance.
Made from raw materials compliant to the European Pharmacopoeia, Simaline L80 in combination with Sepineo™ polymer range is a new solution to formulate a dosage form associating superior solvent/penetration enhancer compatibility, a unique texture and ease of manufacturing. With Simaline L80 and Sepineo™ Polymers, the Geltrap™ ”Gel-in-oil” patented concept associates excipients with Pharmacopoeia-compliance or with precedence of use in drugs to offer new technical solutions.
Solvents and penetration enhancers are essential for a successful solubilization and skin delivery of APIs, though they have a significant impact on the stability of the formula. Geltrap™ emulsion is a solution to formulate major pharmaceutical solvents and penetration enhancers even at high concentrations (PEG-400, diethylene glycol monoethyl ether, propylene glycol, glycerin, …).
The performance of “Gel-in-Oil” emulsions comes along with a unique texture, to guarantee an optimal patient compliance: a fresh, non-greasy touch even with high content of solvents, easy skin spreading, moisturizing and emollient, …
The polymeric character of Simaline L80 is the key to the stability of Geltrap™ emulsions, from the most difficult conditions (room-temperature, low shear manufacturing) to traditional emulsion formulation conditions. The liquid form of Simaline L80 makes for easy handling at all stages of the product development and manufacturing.