Topical formulation of API with low water-solubility

  • March 31, 2022
  • 1 min of read time

Topical formulation of API with low water-solubility

A key challenge faced in topical formulation is the solubilisation of Active Pharmaceutical Ingredients. For a successful drug development, this solubility character is critical and will influence the choice of the excipients and the formulation parameters.

Poor water-solubility is an issue affecting both a large majority of NCE as well as well-known APIs.

API solubility character is a critical factor in topical drug development. A majority of APIs exhibit poor water-solubility, requiring excipient composition and formulation process adjustments.

Among all the solutions available to formulation scientists, the design of an appropriate solvent/co-solvent/solubilizer system matching a given API is key to improve its water-solubility without requiring physico-chemical modifications of this API or complex formulation processes.

Poorly water-soluble API characteristics

Ever formulated with solvents such as PEG-400, diethylene glycol monoethyl ether, propylene glycol or ethanol? Optimize your developments with these practical solvent formulation tips.

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