A key challenge faced in topical formulation is the solubilisation of Active Pharmaceutical Ingredients. For a successful drug development, this solubility character is critical and will influence the choice of the excipients and the formulation parameters.
Poor water-solubility is an issue affecting both a large majority of NCE as well as well-known APIs.
Among all the solutions available to formulation scientists, the design of an appropriate solvent/co-solvent/solubilizer system matching a given API is key to improve its water-solubility without requiring physico-chemical modifications of this API or complex formulation processes.
Ever formulated with solvents such as PEG-400, diethylene glycol monoethyl ether, propylene glycol or ethanol? Optimize your developments with these practical solvent formulation tips.
Looking for effective solubilizers? Find out about our Polysorbate range here.