GIVOCAL™

Calcium glycerophosphate is a source of highly bioavailable calcium and phosphorus. This mineral salt has nutritional, organoleptic and technological superior quality. These qualities are due to the specific characteristics of the organic anion glycerophosphate.

Advantages to use GIVOCAL™

1. A "3 in 1" salt
   It supplies calcium, glycerol and phosphorus
    
2. Double interest
   This type of calcium salt has a physiologic and metabolic interest due to the glycerophosphate, which is absent in inorganic calcium salts
    
3. A superior way
   As part of nutraceuticals or health food, GIVOCAL™ is a highly bioavailable source of calcium
    
4. Scientific evidences
   Calcium glycerophosphate shows excellent absorption. Some other clinical studies show positive effects on bone and teeth development
    
5. A chelate
   Glycerophosphate is an excellent vector for delivering calcium into the GI tract

Bioavailability

Most calcium compounds given orally are soluble in gastric acid but are converted into insoluble calcium carbonate in the duodenum resulting in only a fraction of the calcium is available for absorption. Absorption of calcium salts therefore depends greatly on their solubility and stability in a wide pH range.

A study on the capacity of acidity neutralization made on several calcium salts shows that GIVOCAL™ has the smallest buffer power and therefore is the best solubilized in the stomach among all salts studied. It also stays solubilized in the small intestine.

These results were confirmed by an in vitro study made on the gastrointestinal model TIM-1 of TNO laboratory (The Netherlands) which compared the absorption of GIVOCAL™ and calcium carbonate. With the same amount of calcium ingested (introduced into the system), GIVOCAL™ permits a better absorption of calcium: 4 times more calcium is absorbed with GIVOCAL™ than with calcium carbonate (internal results).

Moreover, a recent study made on rats shows that, with the same amount of calcium ingested, GIVOCAL™ has twice as less of calcium excretion than calcium carbonate (internal results). These results suggest that GIVOCAL™ has a higher bioavailability than calcium carbonate.

Other in vitro or in vivo studies show that GIVOCAL™ allows a good assimilation of calcium by the bone tissue, has a cariostatic effect on teeth and shows a beneficial action on the nervous system (internal results).

Technical information

Composition : 
- Ca/P ratio: 1.3
- 19.1% Ca content
- 14.6% P content

Taste & Odour: Neutral
Solubility: Water soluble
Appearance: Fine white powder

Partner

Isaltis is a leading manufacturer of high quality mineral salts.

Isaltis owns two GMP sites in France, Bernady and Givaudan Lavirotte, where are manufactured glycerophosphate, gluconate, glucoheptonate, citrate and lactate salts.

Seppic distributes Isaltis products in North America.