Covid-19, stress and saffron

  • December 8, 2020
  • 3 mins of read time

Covid-19, stress and saffron

The world as we know it has changed significantly in the post-COVID era. Among US adults, the rate of people newly diagnosed as suffering from depression has tripled1. As we continue to deal with the fallout of the pandemic, the numbers of people dealing with depression, anxiety, and the consequences of long-term stress will likely continue to grow.

Mood disorders, an increasing issue

Stress induces the human body to produce cortisol, the “stress hormone,” which can impact virtually every system in the body2. While short-term cortisol effects are natural and even beneficial, most people are dealing with long-term effects, which can cause symptoms ranging from fatigue, gastrointestinal issues, increased blood pressure, insomnia, and a host of others - most significantly, anxiety and depression.

In the next few years, we will see record numbers of people suffering from these mood disorders. Consumers have shown a steadily-increasing interest in herbal remedies in the previous decades3, so it’s a natural conclusion that they will be looking for naturally-derived remedies for stress. One of the ingredients set to take center stage in this is saffron.

Saffron, a safe and effective solution

Saffron (crocus sativus) is a traditional herbal medication derived from the stigma and style of the autumn crocus flower. It’s been used as a medicinal treatment for over 3,600 years and has been recognized as being as effective for the treatment of depression as imipramine or fluoxetine4,5. However, unlike the pharmaceutical drugs, there were no severe adverse side effects reported with saffron usage. Positive effects in trial participants were noted in as little as one week, on a dosage of 30mg daily, although full effects were usually demonstrated with a minimum of two weeks of usage.

The two key active ingredients in saffron are safranal and crocin7, although it’s composed of over 150 volatile and non-volatile ingredients that work in a complementary manner, including components like crocetin and kaempferol. Studies have shown that safranal acts to inhibit serotonin reuptake, while crocin inhibits dopamine reuptake, making it easier for the brain to balance the levels of neurotransmitters.

This makes saffron a promising alternative for people seeking emotional balance improvement and who would like to avoid the side effects that often come with pharmaceutical remedies. Saffron is uniquely posed to be a safe, effective dietary supplement for people looking for improving their emotional balance. The effectiveness of the saffron extract will highly depend on the quality of the full spectrum of its active compounds beneficial to balance the levels of neurotransmitters in the brain, especially crocin and safranal when measured by HPLC.

Safr'InsideTM - Think positive

Safr'InsideTM has been developed by Activ'Inside to provide the most effective saffron extract for mood benefits. It is the only encapsulated saffron extract, obtained with the patented Tech’care extractionTM,and is the richest extract titrated to safromotivines, including crocin and safranal tested by HPLC.

Discover Safr'InsideTM


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Seppic Nutrition team