SIMALINE L80

Liquid polymeric emulsifier for innovative pharmaceutical "Gel-in-Oil" emulsion and for W/O emulsion

Made of raw materials compliant to the European Pharmacopoeia (Ph. Eur.)

Simaline L80 is a high molecular weight emulsifier imparting robustness and a pleasant sensory profile to innovative Gel-in-oil emulsions and traditional W/O emulsions.

Its liquid nature makes for easy handling for sampling, manufacturing and cleaning operations.

Chemical name: Sorbitan Oleate & PEG-30 dipolyhydroxystearate

Dose: 1.5% to 4%

Applications: Topical, transdermal, vaginal, rectal

Vehicle for high quantities of polar solvents

The polymeric nature of Simaline L80 is essential to formulate a Geltrap™, emulsifying a high content of aqueous internal phase (> 80%) into a Gel-in-Oil emulsion.

This dosage form can incorporate high quantities of polar solvents to promote the solubilization and skin penetration of APIs:

> 50% PEG-400
> 40% Transcutol® P (Diethylene glycol monoethyl ether)
> 80% Propylene glycol
> 60% Glycerin

Geltrap™ can also be a solution for topical formulation of water-sensitive APIs into an anhydrous vehicle.

Promoting patient compliance

The Geltrap™ is a solution to improve the sensory profile of your emulsions even in presence of high quantities of solvents, thanks to its unique texture:

Fresh touch
Non-greasy, non-sticky
Easy skin spreading
Good emolliency even with only 10% of oil phase

Value-adding benefits for topical drugs and medical devices

API solubilization & skin delivery thanks to its compatibility with solvents & penetration enhancers
Moisturizing & emollient vehicle for skin disorders linked to disease (e.g. atopic dermatitis, psoriasis, ichthyosis, ...) or treatment (i.e. retinoids, corticoids, ...)
Ideal sensory profile for pain relief with moderate to long playtime and fresh touch for quick relief
Mucosal applications: water-resistance property for longer contact time

Cost, energy and time-saving technology

The Geltrap™ can be a cost-friendly alternative and a true ally at laboratory and industrial scale:

The possibility of a dosage form rich in water, up to 95% content
Room-temperature, low shear and quick emulsification process thanks to Simaline L80 polymeric nature
Simaline L80: a liquid emulsifier for an easier handling / manufacturing / cleaning