The topical administration of drugs allows targeted care of dermatological or loco-regional pathologies, or by transdermal route. Dermo-pharmaceutical drugs exist largely in semi-solid forms such as gels, creams, foams, and sprays.
During formulation, the choice of excipients is essential in guaranteeing medication efficacy by solubilizing the active ingredients and optimizing their cutaneous penetration, for the stability of the galenic form and its texture, as well as for therapeutic adherence of the patient.
Seppic offers innovative excipients designed to address formulation issues that other excipient cannot. Their safety of use for cutaneous and mucosal applications is guaranteed by tolerance tests. We also provide Pharmacopeia-compliant excipients meeting Ph. Eur. and USP-NF requirements.
Polymer thickeners, stabilizers, and texturing agents
The use of rheology modifiers in semi-solid formulations ensures stability and a texture adapted to the area of application and the pathology.
Sepineo™ polymers are thickening agents with high performance at pH values between 3 and 12, capable of stabilizing large quantities of solvents and lipophilic phases. Their texturizing power facilitates skin adhesion, spreading, and gives a non-greasy and non-tacky feel for optimal patient therapeutic adherence. They can be used in products for topical, transdermal, vaginal, rectal, and gingival routes of administration.