METOLOSE® SM 4
Low-viscosity methylcellulose for film-coating of granules
METOLOSE® SM-4 is a low-viscosity methylcellulose specially designed for film-coating of granules and pellets in fluidised bed.
The METOLOSE® range from SHIN ETSU is compliant with Ph.Eur, JP and USP.
Film-coating of granules and taste masking
In fluidised bed systems, the film-coating of granules and pellets in aqueous medium can be complicated by adhesion phenomena.
METOLOSE® SM-4 is only slightly adhesive and can be used to obtain a fine, consistent film-coating of granules and pellets using fluidised air bed systems without agglomeration due a reduced adhesiveness.
At a spray rate of 80 g/min, fewer than 5% of 1 mm granules are agglomerated while with hypromellose, this rate is almost 50% for the same spraying speed.
- The granules film-coated with METOLOSE® SM-4 do not show any dispersion delay.
- The product is used at a concentration of 7% in aqueous medium.
- METOLOSE® SM-4 also has taste masking properties.
- METOLOSE® SM-4 is manufactured in accordance with the Good Manufacturing Practices applicable to excipients.
All the regulatory and quality documents needed for registration are available on request.
The Japanese company SHIN ETSU is a leader in cellulose chemistry.
SHIN ETSU develops pharmaceutical excipients and particularly cellulosic polymers for a range of applications such as film-coating, compression and matrices.
SEPPIC™ distributes SHIN ETSU products in Western and Southern Europe and several other countries.