MONTANIDE™, adjuvant solutions for avian vaccines needs
Vaccines are the most commonly administered veterinary medicines in poultry production. They have had a major impact on the development of the poultry industry thanks to an effective prevention and control of diseases in the field. Vaccine adjuvants also contributed to this main development. SEPPIC offers a dedicated range of adjuvants for avian vaccination.
MONTANIDE™ for avian vaccines
The aim of each poultry vaccination program is to stimulate the most appropriate immune responses against the disease in the target animal (broilers, breeders, layers). The choice of the adjuvant in the vaccine must consider several criteria: the disease, the type of antigen (live or inactivated), the immune response kinetics (short or long term protection), the types of immune response (humoral and/or cellular) and the administration route (injection or mass vaccination).
For injectable vaccines, the adjuvant technology usually recommended is:
- Water-in-Oil emulsion: MONTANIDE™ ISA
This adjuvant technology can be used with mono or multivalent inactivated antigens.
SEPPIC also provides adjuvant solutions for mucosal administration for mass vaccination for both live and inactivated antigens. Mucosal administration of vaccines, through oral, spray or intranasal routes reduces vaccination time by mass vaccination, and reduces safety risk, while increasing the specific local immune response. An adjuvant used in a mucosal vaccine has to be aqueous, safe and efficient in stimulating the mucosal immune system.
SEPPIC polymer and micro-emulsions technologies answer these criteria with MONTANIDE™ GEL and MONTANIDE™ IMS.
A team of experts can assist customers in the selection of the most efficient adjuvants to suit their models.
MONTANIDE™ in the field
MONTANIDE™ adjuvants are being used worldwide in avian species vaccines against viral, bacterial or parasitic diseases, such as:
- Pasteurella multocida
- Avian influenza (AI)
- Newcastle disease (ND)
- Egg drop syndrome (EDS)
- Infectious bronchitis (IB)
- Marek's disease
In ovo vaccination is a fast and efficient method which allows poultry vaccination in the hatchery.
It is being used in commercial applications throughout the poultry industry, especially for Marek’s disease vaccination in North America. In ovo vaccination consists in the injection of vaccine in embryonated eggs at 18 or 19 days of incubation (2-3 days before hatch), using a specific equipment. In ovo vaccine can be applied to 50,000 to 100,000 eggs per hour.
To develop inactivated or subunit vaccines for in ovo injection, efficient and egg-compatible adjuvants should be used. Classical oil vaccines are most of the time toxic for egg administration. In order to offer an adapted adjuvant for in ovo vaccines, SEPPIC has screened placebo vaccines based on different adjuvant technologies for their safety profile after egg injection at 18 days of incubation and developed dedicated adjuvants for in ovo vaccination.