Biology and immunology
At SEPPIC, the synergies we build between our cross-disciplinary areas of expertise represent one of our major strengths. Drawing on the excellence of our biology and immunology laboratories, and the cutting edge skills of our teams of biologists, we use the most demanding criteria when testing our products for both cosmetics and vaccine adjuvants.
Cosmetics: assessing efficacy and tolerance
Thanks to our teams' expertise and state-of-the-art facilities, our biology laboratories are fully equipped to carry out a range of molecule efficacy assessments:
- biochemical evaluations (spectrophotometry, fluorimetry, etc.),
- protein expression evaluations (immunomarking, Western-blot, ELISA),
- histological evaluations (paraffin, freezing),
- cellular analysis, including gene/transcriptome expression,
- transcutaneous passage evaluations,
- clinical evaluations of cosmetic active substances, in partnership with private clinical trial companies,
- cross-disciplinary studies to develop cosmetology research.
These evaluations can be carried out on different cellular types: tissue (human skin for instance), reconstructed tissue models, skin and non-skin cells.
Before commercializing our products, we ensure that all of the ingredients used are completely safe. Preliminary toxicity tests are conducted in our laboratories. Our experts fully understand the main alternative evaluation protocols such as the HET-CAM and RBCA eye irritation tests, and the skin irritation evaluation of reconstructed tissue. The other toxicity tests are carried out in partnership with companies specializing in toxicology studies.
Vaccines: immunology and immuno-investigation
At SEPPIC, our unique expertise spans the entire life cycle of vaccine adjuvants and vaccine injectables for humans (therapeutic vaccines, medicines), livestock and pets.
Our team of immunologists works in a combined research unit at the National Veterinary School at Maisons-Alfort, near Paris. For over 15 years, the team has tested the capacity of SEPPIC's vaccine adjuvants to trigger a strong immunological response without generating side effects.
Adjuvant formula performance must be evaluated before testing. Approved adjuvants are then proposed to pharmaceutical laboratories for the development of vaccines.
Strength through unity
At SEPPIC we work with different technologies to develop the type and intensity of the immunological response triggered by our vaccine adjuvants.
- ELISA (Enzyme Linked Immuno Sorbant Assay):a method to detect immune system antibodies and soluble molecules in the serum of vaccinated animals.
- FACS (Flow Cytometry Analysis): a technology to study the nature of cells present in biological samples and in vitro cultures. It can also be used to detect and gather information about these cells, such as their identity, biological activity and activation level.
- Immunohistochemistry: a method to analyze how vaccines react to the injection site. This technology can be used to evaluate the metabolization and elimination of injected molecules.