Cosmetogenomics: SEPICALM S puts inflammation genes to the test

SEPPIC uses gene analysis to demonstrate the effectiveness of its soothing active ingredient SEPICALM S. A study was conducted at its biology laboratory on 60 genes involved in the inflammation process and in cellular stress.

SEPICALM S controls the genes primarily responsible for the inflammatory reaction induced in stressed skin cells (UVA and UVB radiation). It modulates key inflammation transcription factors either positively (TP53) or negatively (AP-1, NFkB), thus minimizing synthesis of the agents responsible for its propagation: proinflammatory cytokines (Interleukin-1α, 6, 8), tumor necrosis factor (TNF), C-C chemokine ligand (CCL), enzymes involved in the arachidonic acid metabolism (ALOX, PTG) or in the degradation of the extracellular matrix (MMP), and proapoptotic proteins (BAX).

By acting at the heart of the cell, this soothing active agent by SEPPIC significantly reduces skin redness and burning or discomfort (4 in vivo tests). SEPPIC offers to formulators the assurance of an effective product, demonstrated using high technology methods. SEPICALM S is the ideal solution for relieving sensitive and irritated skin!

Yohanna Sander, Active Products Manager at SEPPIC stated:
“SEPICALM S is SEPPIC’s benchmark active ingredient that illustrates the “cosmeto’hedonist” concept: it combines science (clinically proven in vivo and in vitro) and pleasure (softness, well-being, comfort) to relieve sensitive or irritated skin. Using cosmetogenomics to decode its ability to stop inflammation in its tracks “certifies” its protective and soothing role in all types of cutaneous stress!”